A Comprehensive Toxicological Assessment of Fulvic Acid

Table 1

The changes in total average daily food intake, water intake, and body weight gain during the 60-day repeated-dose oral toxicity studies of FA.

Index	Female				Male
	Control	200 mg/kg BW	1, 000 mg/kg BW	5, 000 mg/kg BW	Control	200 mg/kg BW	1,000 mg/kg BW	5, 000 mg/kg BW
During 0-30 th day
Total average food intake (g/day/rat)	12.04 ± 0.08	12.34 ± 0.09	12.32 ± 0.10	12.28 ± 0.08	15.58 ± 0.07	14.89 ± 0.08	15.26 ± 0.07	15.09 ± 0.14
Total average water intake (g/day/rat)	27.51 ± 0.70	28.19 ± 0.82	28.15 ± 0.88	28.06 ± 073	35.80 ± 0.61	34.21 ± 0.77	35.08 ± 0.67	34.69 ± 1.24
Total average daily body weight gain (g/day/rat)	3.52 ± 1. 19	3.65 ± 0.73	3.63 ± 0.73	3.55 ± 0.71	5.96 ± 1.00	5.70 ± 1.14	5.77 ± 1.15	5.74 ± 1.12
During 31st–60th day
Total average food intake (g/day/rat)	22.74 ± 0.11	23.46 ± 0.29	23.17 ± 0.12	23.57 ± 0.16	35.00 ± 0.07	34.34 ± 0.29	34.00 ± 0.11	35.40 ± 1.17
Total average water intake (g/day/rat)	47.18 ± 0.46	48.67 ± 1.20	48.08 ± 0.51	48.90 ± 0.65	74.97 ± 0.30	73.53 ± 1.27	72.83 ± 0.45	75.79 ± 5.01
Total Average daily body weight gain (g/day/rat)	1.67 ± 0.83	1.72 ± 0.34	1.79 ± 0.36	1.95 ± 0.39	4.24 ± 0.56	4.33 ± 0.87	4.11 ± 0.82	4.09 ± 0.82

No statistically significant differences were found, compared to the corresponding control group.