Ginsenoside Rg1 Drives Stimulations of Timosaponin AIII-Induced Anticancer Effects in Human Osteosarcoma Cells
Stimulations of Rg1 on TA3-induced antimetastatic effects in U2OS human osteosarcoma cells. (a) Rg1 and TA3 synergistically attenuate the migration of U2OS cells. Recovery of the wound width on the center of the cell surface was inhibited most when the cells were treated with Rg1 and TA3 together. Cells were treated with 0.1% FBS for negative control. The wound widths were measured for the quantitation. (b) Rg1 and TA3 synergistically inhibit gelatinase activities of MMP-2 and MMP-9. (c) Transcriptional expressions of MMP-2 and MMP-9 were downregulated further by the combinatorial treatment of Rg1 (250 μM) and TA3 (6 μM) in U2OS cells. The results were analyzed statistically by ANOVA and Tukey’s test (, vs control, vs treatment of TA3, vs treatment of Rg1).
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