Antimalarial Activity of Meriandra dianthera Leaf Extracts in Plasmodium berghei-Infected Mice

Table 2

Effect of the hydromethanolic leaf extract of M. dianthera on rectal temperature and body weight of P. berghei-infected mice.

Test sample	Dose (mg/kg)	Rectal temperature (°C)			Body wt. (g)
		D0	D4	% of change	D0	D4	% of change
NC	10 ml/kg	36.0 ± 0.40	35.05 ± 0.08	−2.58 ± 1.00	29.15 ± 0.70	28.70 ± 0.82	−1.53 ± 0.71
Extract	200	35.90 ± 0.24	35.48 ± 0.26	−2.23 ± 1.09	29.97 ± 0.70	31.67 ± 0.65	1.95 ± 1.32
Extract	400	36.02 ± 0.29	35.78 ± 0.45	−0.64 ± 0.90	32.48 ± 0.80	33.38 ± 0.55	5.89 ± 1.66
Extract	600	36.40 ± 0.18	35.58 ± 0.25	−1.14 ± 0.83	29.54 ± 2.11	30.66 ± 2.06	4.02 ± 1.50
CQ	25	35.90 ± 0.24	36.28 ± 0.13	1.07 ± 0.49	25.23 ± 0.56	25.54 ± 0.64	1.46 ± 2.82

Values are presented as Mean ± SEM, n = 6; CQ = chloroquine phosphate; NC = negative control; as compared to NC; D₄ = day 4; D₀ = day 0.