Antimalarial Activity of Meriandra dianthera Leaf Extracts in Plasmodium berghei-Infected Mice

Table 3

Effect of solvent fractions of M. dianthera on mean parasitaemia level and mean survival time of P. berghei-infected mice.

Fraction/drug	Dose (mg/kg)	% of parasitaemia	% of suppression	MST (days)
NC	10 ml/kg	43.5 ± 1.52	0.00	7.33 ± 0.21
AF	200	36.27 ± 5.26	13.50	8 ± 0.45
	400	28.68 ± 3.00^a	34.07	8.5 ± 0.5
BF	200	38.07 ± 1.92	13.30	8.17 ± 0.60
	400	31.90 ± 3.42	23.30	7.67 ± 0.21^b
CF	200	31.6 ± 1.56	24.30	8.5 ± 0.56
	400	28.18 ± 3.78^a	35.21	10 ± 0.77^a
EF	200	38.67 ± 1.42	7.51	8.17 ± 0.40
	400	34.70 ± 5.07	17.1	8 ± 0.37
CQ	25	0.00^a	100.00	ND

Values are expressed as Mean ± SEM; n = 6; CQ = chloroquine phosphate; NC = negative control; AF = aqueous fraction; BF, butanol fraction; CF = chloroform fraction; EF = ethyl acetate fraction; ; ; ^awhen compared to NC; ^bwhen compared to CF400 mg/kg; ND = no death within the follow-up period; MST = mean survival time in days.