Antimalarial Activity of Meriandra dianthera Leaf Extracts in Plasmodium berghei-Infected Mice

Table 4

Effect of solvent fractions of M. dianthera on rectal temperature and body weight of P. berghei-infected mice.

Test sample	Dose (mg/kg)	Rectal temperature (°C)			Body wt. (g)
		D0	D4	% of change	D0	D4	% of change
NC	10 ml/kg	36.35 ± 0.16	35.5 ± 0.32	−2.32 ± 1.17	25.48 ± 2.22	25.07 ± 2.07	−1.40 ± 1.40
AF	200	36.1 ± 0.36	35.53 ± 0.31	−1.67 ± 1.11^b	24.3 ± 1.75	25.9 ± 2.03	6.38 ± 1.24^d^e
	400	35.9 ± 0.23	36.33 ± 0.25	1.22 ± 0.80^c	24.3 ± 1.75	25.9 ± 2.03	6.38 ± 1.24^d^e
BF	200	36.8 ± 0.46	36.97 ± 0.29	0.47 ± 1.28^c	24.23 ± 1.79	26.25 ± 0.81	8.5 ± 1.3^c^e^d
	400	36.8 ± 0.41	36.17 ± 0.19	−1.79 ± 1.1^b	24.02 ± 1.65	25.82 ± 0.94	8.5 ± 3.1^c^d^e
CF	200	36 ± 0.25	36.1 ± 0.19	0.29 ± 0.69^c	28.43 ± 0.84	29.38 ± 0.71	3.43 ± 0.84^d
	400	35.17 ± 1.24	36.17 ± 1.04	2.98 ± 0.84^d	26.83 ± 2.48	27.68 ± 0.11	3.87 ± 1.85^d
EF	200	36.68 ± 0.17	34.13 ± 0.21	−6.9 ± 0.9^a^e	22.13 ± 0.80	23.65 ± 0.97	5.23 ± 2.19^d^e
	400	36.03 ± 0.11	35.52 ± 0.19	−0.43 ± 0.61^bc	23.18 ± 1.13	25.37 ± 1.12	9.6 ± 1.8^c^d^e
CQ	25	36.87 ± 0.30	36.92 ± 0.29	0.15 ± 0.47^c	30.67 ± 1.14	30.9 ± 0.73	1.04 ± 1.67

Values are presented as Mean ± SEM; n = 6; CQ, chloroquine phosphate; NC, negative control; AF, aqueous fraction; BF, butanol fraction; CF, chloroform fraction; EF, ethyl acetate fraction; ; ; ; ^acompared to AF 400 mg/kg; ^bcompared to CF 400 mg/kg; ^ccompared to EF 200 mg/kg; ^dcompared to NC; ^ecompared to CQ treated group.