Houttuynia cordata Extract Ameliorates Bladder Damage and Improves Bladder Symptoms via Anti-Inflammatory Effect in Rats with Interstitial Cystitis

Figure 1

Houttuynia cordata extract restored bladder damage and inhibited mast cell proliferation and activation. (a) Hematoxylin-eosin staining (×100) of the sham group. (b) Hematoxylin-eosin staining (×100) of the CYP + NS group: inflammatory cell infiltration, urothelial injury, submucosal edema, and hemorrhage were observed obviously. (c) Hematoxylin-eosin staining (×100) of the CYP + HC group, inflammatory reaction of bladder tissue improved. (d) Toluidine blue staining (×400) of the sham group: few mast cells and no activated mast cells were observed.(e) Toluidine blue staining (×400) of the CYP + NS group, large numbers of mast cells were observed and most of them were activated mast cells. (f) Toluidine blue staining (×400) of the CYP + HC group: fewer number of mast cells and activated mast cells were observed. (g) Inflammatory grade of the CYP + HC group was significantly lower than that of the CYP + NS group. (h) Number of mast cells of the CYP + HC group was fewer than that of the CYP + NS group. (i) Proportion of activated mast cells of the CYP + HC group was fewer than that of the CYP + NS group. vs. the sham group; vs. the CYP + NS group.

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