Zi Shen Huo Luo Formula Prevents Aldosterone-Induced Cardiomyocyte Hypertrophy and Cardiac Fibroblast Proliferation by Regulating the Striatin-Mediated MR/EGFR/ERK Signaling Pathway

<div>Hypothetical model describing the striatin-mediated signaling pathway. After binding striatin, MR is translocated to and associated with the cell membrane to form a signaling complex. On aldosterone stimulation, the EGFR/ERK signaling pathway is activated, resulting in cell proliferation and fibrosis.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 8

Figure 8: Zi Shen Huo Luo Formula Prevents Aldosterone-Induced Cardiomyocyte Hypertrophy and Cardiac Fibroblast Proliferation by Regulating the Striatin-Mediated MR/EGFR/ERK Signaling Pathway 

Figure 8 | Zi Shen Huo Luo Formula Prevents Aldosterone-Induced Cardiomyocyte Hypertrophy and Cardiac Fibroblast Proliferation by Regulating the Striatin-Mediated MR/EGFR/ERK Signaling Pathway 