Evidence-Based Complementary and Alternative Medicine / 2020 / Article / Fig 8

Research Article

Zi Shen Huo Luo Formula Prevents Aldosterone-Induced Cardiomyocyte Hypertrophy and Cardiac Fibroblast Proliferation by Regulating the Striatin-Mediated MR/EGFR/ERK Signaling Pathway

Figure 8

Hypothetical model describing the striatin-mediated signaling pathway. After binding striatin, MR is translocated to and associated with the cell membrane to form a signaling complex. On aldosterone stimulation, the EGFR/ERK signaling pathway is activated, resulting in cell proliferation and fibrosis.

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