Qingxin Kaiqiao Fang Inhibits A<i>β</i><sub>25-35</sub>-Induced Apoptosis in Primary Cultured Rat Hippocampal Neuronal Cells via the p38 MAPK Pathway: An Experimental Validation and Network Pharmacology Study

<div>A<i>β</i> treatment significantly overexpressed Bax protein and has a little effect on reducing the expression of Bcl2 protein. These changes released cytochrome c from mitochondria, which resulted in activation of the caspase cascade, including caspase-3, the downstream protein of the caspase family. The activation of caspase cascade indirectly stimulated p38 MAPK, resulting in p38 MAPK phosphorylation. Finally, p-p38 MAPK led to apoptosis. QKF enhanced the expression of Bcl-2 and reduced the expression of Bax and cleaved caspase-3, thus affecting subsequent steps.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 9

Figure 9: Qingxin Kaiqiao Fang Inhibits A<i>β</i><sub>25-35</sub>-Induced Apoptosis in Primary Cultured Rat Hippocampal Neuronal Cells via the p38 MAPK Pathway: An Experimental Validation and Network Pharmacology Study 

Figure 9 | Qingxin Kaiqiao Fang Inhibits Aβ25-35-Induced Apoptosis in Primary Cultured Rat Hippocampal Neuronal Cells via the p38 MAPK Pathway: An Experimental Validation and Network Pharmacology Study 