[Retracted] Improving Small Intestinal Motility in Experimental Acute Necrotising Pancreatitis by Modulating the CPI-17/MLCP Pathway Using Chaiqin Chengqi Decoction

Figure 2

Effects of CQCQD and CCh on intestinal histopathology and serum intestinal motility biomarkers. Rats received 2 intraperitoneal injections of L-ornithine (Orn; 3.0 g/kg; pH 7.0) at 1 hour apart and controls received the same regimen of normal saline injections. In the treatment groups, rats either received single intraperitoneal injection of carbachol (CCh; 60 μg/kg) or 3 times oral gavage of chaiqin chengqi decoction (CQCQD; 20 g/kg) at 2-hourly interval begun at 24 hours after the first L-ornithine injection. Rats were sacrificed at 30 hours to assess severity of acute pancreatitis. (a) Representative H&E sections of upper jejunum (100x). (b) Intestinal pathology scores: A, overall; B, crypt damage; C, inflammation severity; D, inflammation extent. (c) Serum vasoactive intestinal peptide (VIP). (d) Serum intestinal fatty acid-binding protein (iFABP). vs. saline group; vs. L-ornithine group. Values are means ± SEM of 5–10 animals per group.

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