Ulmus parvifolia Jacq. Exhibits Antiobesity Properties and Potentially Induces Browning of White Adipose Tissue

Figure 4

UP reduced the size of mice and mouse livers and improved the histology of the liver and adipose tissue induced by an HFD. Mice were fed with an HFD for a total of 12 weeks, and oral administration of orlistat and UP was carried out after 4 weeks of a daily HFD. Representative images of mice and livers for each group (a-b). Liver tissues and epididymal adipose tissue were dehydrated and fixed in paraffin and then sectioned before staining with H&E (c-d). Liver tissues (c) and epididymal adipose tissue (d) were observed at 100x. Arrows indicate balloon cells, and arrowheads indicate the infiltration of inflammatory cells. CV indicates the location of the central vein, whereas PV indicates the portal veins. Magnified image of the CV area of the liver tissue in HFD-treated group was taken at 200x. Statistical analysis for adipocyte count performed using one-way ANOVA with Dunnett’s posttest, and indicates compared to the HFD group, whereas indicates a as compared to the control group.

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