Ulmus parvifolia Jacq. Exhibits Antiobesity Properties and Potentially Induces Browning of White Adipose Tissue

Figure 7

Schematic diagram of the proposed mechanism of action of UP. UP increased the browning of WAT by acting through increased AMPKα expression, which, in turn, increases PPARγ expression followed by the increase of PGC-1α expression, which induces upregulation of mitochondrial UCP-1 in white adipocytes and increases the usage of stored triglycerides and thermogenesis. Phosphorylation of ACC was also inhibited, subsequently inhibiting lipid synthesis.