Evidence-Based Complementary and Alternative Medicine

Research Article

Antimalarial Activity of Crude Extract and Solvent Fractions of the Leaves of Bersama abyssinica Fresen. (Melianthaceae) against Plasmodium berghei Infection in Swiss Albino Mice

Table 3

Effect of B. abyssinica crude extract and solvent fractions on body weight and rectal temperature of P. berghei-infected mice in the 4-day suppressive test.


Group	Body weight (g) ± SEM			Rectal temperature (°c) ± SEM
Group	D0	D4	% change	D0	D4	% change

DW 10 ml/kg	30.26 ± 0.55	28.00 ± 0.58	−7.47	36.70 ± 0.30	34.02 ± 0.22	−7.30
BA 100 mg/kg	27.42 ± 1.11	26.42 ± 0.86	−3.89	36.68 ± 0.19	35.25 ± 0.36	−3.77
BA 200 mg/kg	28.38 ± 0.51	27.51 ± 0.81	−3.14	36.35 ± 0.28	34.97 ± 0.21	−3.79
BA 400 mg/kg	28.76 ± 0.81	27.85 ± 0.95	−3.24	36.35 ± 0.28	35.08 ± 0.18	−3.48
CQ 25 mg/kg	27.94 ± 1.49	28.02 ± 1.36	0.29^a3	36.13 ± 0.71	36.15 ± 0.15	0.08^a3
DW 10 ml/kg	30.04 ± 1.78	25.39 ± 1.24	−15.48	36.18 ± 0.12	34.72 ± 0.32	−4.04
AQ 100 mg/kg	26.99 ± 0.76	24.38 ± 0.53	−8.27	36.48 ± 0.23	35.88 ± 0.22	−1.64
AQ 200 mg/kg	28.48 ± 1.02	26.64 ± 1.06	−6.46	36.52 ± 0.21	35.92 ± 0.18	−1.63
AQ 400 mg/kg	27.52 ± 0.68	26.21 ± 1.65	−5.03	36.34 ± 0.14	35.76 ± 0.81	−1.51
EA 100 mg/kg	31.73 ± 0.90	29.14 ± 1.16	−7.32	36.42 ± 0.26	35.90 ± 0.23	−1.79
EA 200 mg/kg	29.40 ± 0.76	27.32 ± 1.39	−7.07	36.37 ± 0.16	35.72 ± 0.36	−1.79
EA 400 mg/kg	32.57 ± 1.36	29.91 ± 1.41	−8.15	36.20 ± 0.23	35.80 ± 0.20	−1.10
CH 100 mg/kg	31.15 ± 0.45	28.28 ± 0.71	−9.19^b1	36.20 ± 0.18	34.92 ± 0.31	−3.54^b3
CH 200 mg/kg	29.43 ± 1.13	26.71 ± 0.43	−9.24^b1	35.95 ± 0.22	34.85 ± 0.28	−3.06^b2
CH 400 mg/kg	30.30 ± 1.34	27.63 ± 1.09	−8.81^b1	35.82 ± 0.23	34.87 ± 0.35	−2.65^b2
CQ 25 mg/kg	26.19 ± 1.11	26.43 ± 1.03	0.92^a3	35.92 ± 0.28	36.57 ± 0.18	1.81^a3

Data are expressed as mean ± SEM; n = 6, a = compared to distilled water, b = compared to chloroquine 25 mg/kg, 1 = , 2 = , 3 = , = negative and positive controls used for crude extract in the 4 day suppressive test, DW = distilled water, BA = B. abyssinica crude extract, EA = ethyl acetate fraction, CH = chloroform fraction AQ = aqueous fraction, CQ = chloroquine, SEM = standard error of mean, D0 = day 0, and D4 = day 4.