Antimalarial Activity of Crude Extract and Solvent Fractions of the Leaves of Bersama abyssinica Fresen. (Melianthaceae) against Plasmodium berghei Infection in Swiss Albino Mice
Table 5
Effect of B. abyssinica crude extract and aqueous fraction on body weight and rectal temperature of P. berghei-infected mice in Rane’s test.
Group
Body weight (g) ± SEM
Rectal temperature (°C) ± SEM
D3
D7
% change
D3
D7
% change
DW 10 ml/kg
24.84 ± 1.86
22.10 ± 2.12
−11.03
35.17 ± 0.18
33.53 ± 0.34
−4.64
BA 100 mg/kg
25.90 ± 0.47
23.01 ± 0.79
−10.45
35.37 ± 0.37
34.23 ± 0.21
−3.17
BA 200 mg/kg
27.84 ± 0.64
24.90 ± 0.85
−10.56
35.65 ± 0.37
34.47 ± 0.30
−3.28
BA 400 mg/kg
28.74 ± 0.95
26.42 ± 0.84
−8.07
36.00 ± 0.28
34.90 ± 0.32
−3.04
AQ 100 mg/kg
24.55 ± 1.86
22.54 ± 0.64
−9.10
35.73 ± 0.42
34.26 ± 0.30
−4.07
AQ 200 mg/kg
27.28 ± 0.94
24.76 ± 0.66
−9.24
35.35 ± 0.25
34.00 ± 0.40
−3.79
AQ 400 mg/kg
27.18 ± 0.33
25.44 ± 1.21
−6.40
35.02 ± 0.30
33.93 ± 0.53
−3.07
CQ 25 mg/kg
28.37 ± 1.16
28.17 ± 1.04
−0.60a1
35.65 ± 0.46
36.36 ± 0.26
2.07a1
Data are expressed as mean ± SEM; n = 6, a = compared to DW, 1 = , 2 = , 3 = , DW = distilled water, BA = Bersama abyssinica crude extract, AQ = aqueous fraction, CQ = chloroquine, SEM = standard error of the mean, D3 = day 3, and D7 = day 7.
