Antimalarial Activity of Crude Extract and Solvent Fractions of the Leaves of Bersama abyssinica Fresen. (Melianthaceae) against Plasmodium berghei Infection in Swiss Albino Mice

Table 6

Effect of B. abyssinica crude extract and aqueous fraction on percentage parasitemia and survival time of P. berghei-infected mice in the prophylactic test.

Treatment	% parasitemia (±SEM)	% suppression	MST (days) (±SEM)
DW 10 ml/kg	30.30 ± 1.30	0.00	7.83 ± 0.87
BA 100 mg/kg	22.10 ± 0.93	27.06^a3,b3	11.33 ± 0.71^a1,b3
BA 200 mg/kg	19.65 ± 1.22	35.15^a3,b3	12.17 ± 0.95^a2,b3
BA 400 mg/kg	16.93 ± 1.00	44.11^a3,b3,c2	14.67 ± 0.88^a3,b3,c1
AQ 100 mg/kg	22.98 ± 1.06	24.16^a2,b3	9.83 ± 1.45^b3
AQ 200 mg/kg	21.20 ± 0.75	30.03^a3,b3	11.33 ± 1.12^a1,b3
AQ 400 mg/kg	19.07 ± 2.10	37.07^a3,b3	13.50 ± 1.65^a2,b3
CQ 25 mg/kg	0.30 ± 0.18	99.01^a3	29.60 ± 0.40^a3

Data are expressed as mean ± SEM; n = 6, a = compared to DW, b = compared to chloroquine 25 mg/kg, c = compared to BA 100 mg/kg, 1 = , 2 = , 3 = , DW = distilled water, BA = Bersama abyssinica crude extract, AQ = aqueous fraction, CQ = chloroquine, SEM = standard error of the mean, MST = mean survival time.