Antimalarial Activity of Crude Extract and Solvent Fractions of the Leaves of Bersama abyssinica Fresen. (Melianthaceae) against Plasmodium berghei Infection in Swiss Albino Mice

Table 7

Effect of B. abyssinica crude extract and aqueous fraction on body weight and rectal temperature of P. berghei-infected mice in the prophylactic test.

Group	Wt (g) ± SEM			T (°c) ± SEM
	D0	D7	% change	D0	D7	% change
DW 10 ml/kg	24.17 ± 1.97	21.41 ± 0.91	−11.42	36.57 ± 0.22	34.85 ± 0.28	−4.70
BA 100 mg/kg	24.12 ± 0.36	22.10 ± 0.62	−8.43	37.17 ± 0.14	36.18 ± 0.24	−2.64
BA 200 mg/kg	26.39 ± 0.73	24.16 ± 0.68	−8.45	36.88 ± 0.25	36.03 ± 0.15	−2.28
BA 400 mg/kg	25.64 ± 0.34	23.58 ± 0.40	−8.03	36.78 ± 0.12	35.97 ± 0.20	−2.22
AQ 100 mg/kg	23.36 ± 0.58	21.39 ± 0.49	−8.46	36.65 ± 0.14	35.67 ± 0.30	−2.68
AQ 200 mg/kg	24.07 ± 0.64	22.09 ± 0.78	−8.24	37.17 ± 0.24	36.25 ± 0.16	−2.45
AQ 400 mg/kg	25.67 ± 1.29	23.48 ± 1.17	−8.30	37.20 ± 0.21	36.37 ± 0.32	−2.23
CQ 25 mg/kg	23.26 ± 1.05	23.85 ± 1.16	2.54^a1	36.52 ± 0.22	36.72 ± 0.17	0.55^a2

Data are expressed as mean ± SEM; n = 6, a = compared to DW, 1 = , 2 = 1, 3 = , DW = distilled water, BA = Bersama abyssinica crude extract, AQ = aqueous fraction, CQ = chloroquine, SEM = standard error of mean, MST = mean survival time, D0 = day 0, D7 = day 7, T = temperature, and Wt = body weight.