Shikonin Inhibits Der p 2-Induced Cytokine and Chemokine Expression in Dendritic Cells in Patients with Atopic Dermatitis

Table 3

Basal level of the cytokine profile from healthy controls and patients with atopic dermatitis.

	Healthy subject (n = 7)		AD patient (n = 10)		value
	Mean	SD	Mean	SD
IL-1β	0.4	±0.4	1.1	±1.6	0.732
IL-1ra	312.3	±571.7	680.5	±612.1	0.040
IL-2	1.9	±1.5	2.2	±1.3	0.557
IL-4	0.3	±0.2	0.5	±0.4	0.435
IL-5	0.8	±1.2	0.8	±1.2	0.913
IL-6	1.5	±1.2	1.2	±0.7	0.733
IL-7	0.7	±1.9	3.2	±4.8	0.101
IL-8	20.7	±5.2	70.2	±87.4	0.845
IL-9	7.0	±5.5	12.3	±12.2	0.526
IL-10	2.0	±1.0	2.7	±1.7	0.435
IL-12 (70)	3.0	±2.1	2.1	±1.8	0.464
IL-13	0.3	±0.4	1.5	±2.1	0.157
IL-15	9.6	±8.9	10.9	±9.2	0.696
IL-17A	11.5	±5.4	7.3	±3.8	0.051
Eotaxin	2.7	±1.6	3.0	±2.3	0.884
Basic FGF	27.7	±11.4	30.8	±19.6	0.626
G-CSF	11.4	±19.8	12.4	±9.3	0.187
GM-CSF	92.3	±44.4	90.7	±65.0	0.626
IFN-γ	4.3	±6.4	5.9	±3.7	0.239
IP-10	1.4	±2.7	1.2	±2.0	0.819
MCP-1	122.7	±76.4	66.8	±63.8	0.079
MIP-1α	15.0	±17.1	25.2	±29.7	0.558
MIP-1β	45.9	±44.2	81.8	±98.8	0.922
PDGF-BB	3.7	±2.1	5.9	±5.9	0.695
RANTES	17.3	±35.6	5.5	±2.5	0.406
TNF-α	6.3	±10.6	2.6	±1.8	0.806
VEGF	28.0	±35.6	19.7	±23.3	0.625

Data are expressed as the mean ± standard deviation. Data were analyzed using the Wilcoxon signed-rank test.