Research Article

Sorafenib and Mesenchymal Stem Cell Therapy: A Promising Approach for Treatment of HCC

Figure 4

TUNEL staining in the HCC xenograft mice model (magnification, 200×). Green-fluorescent-stained cell nucleus indicates apoptotic cells; red-stained cells represent normal proliferative tumoral cells. (a) Control; (b) Sora; (c) hpMSC (IV); (d) hpMSC (local); (e) hpMSC (IV) + Sora; and (f) hpMSC (local) + Sora, HCC: hepatocellular carcinoma. (g) The diagram shows a quantitative evaluation of apoptotic cells. The mean percentage of apoptotic-positive cells significantly increased in hpMSC (local) + Sora compared with other treatment groups, , , and vs. control. and vs. Sora.