Resveratrol Treatment Is Associated with Lipid Regulation and Inhibition of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in Rabbits Fed a High-Fat Diet

Table 2

Biochemical analysis of rabbits from NDG (n = 8), FDG (n = 8), and RFG (n = 8) analyzed at the end of the 3-month fat diet.

	NDG (n = 8)	FDG (n = 8)	RFG (n = 8)	F	value
Weight (kg)^#	2.90 ± 0.08	2.98 ± 0.15	2.96 ± 0.07	1.160	0.333
ALT	44.81 ± 7.95	50.86 ± 24.53	61.06 ± 20.26	1.506	0.245
AST^#	40.51 ± 6.46	84.32 ± 54.94	77.91 ± 24.54^a	3.668	0.043
CREA	77.38 ± 10.45	111.92 ± 11.38^a	127.63 ± 10.84^a,b	44.526	<0.001
TG	0.62 ± 0.21	0.90 ± 0.42	0.76 ± 0.28	1.567	0.232
TC^#	2.19 ± 0.30	30.32 ± 5.74^a	11.84 ± 2.78^a,b	120.264	<0.001
HDL^#	1.03 ± 0.20	3.28 ± 1.61^a	1.58 ± 0.35^a	11.946	<0.001
LDL	0.91 ± 0.22	16.45 ± 3.16^a	6.23 ± 1.53^a,b	120.880	<0.001
Lp-PLA2^#	520.14 ± 51.55	1928.88 ± 385.78^a	953.20 ± 96.66^a,b	77.698	<0.001

^#The test result of homogeneity of variance was , and Dunnett’s T method was used for multiple comparison of value correction, while the Bonferroni method was used for the other indicators. NDG, normal diet group; FDG, fat diet group; RFG, fat diet with resveratrol; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CREA, creatinine; TG, triglycerides; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; Lp-PLA2, lipoprotein-associated phospholipase A2. ^aStatistically significant when compared to NDG at . ^bStatistically significant when compared to FDG at .