In Vivo Evaluation of Wound Healing and Anti-Inflammatory Activity of 80% Methanol Crude Flower Extract of Hagenia abyssinica (Bruce) J.F. Gmel in Mice

Table 3

Activity of topical application of the 80% methanolic extract of the flower of H. abyssinica on the wound area of the excision wound model in mice.

Wound area (mm^2) (mean ± SEM) postwounding days
Day	SO	NF	5% CEO	10% CEO
0	311.13 ± 1.30	311.33 ± 1.38	312.50 ± 0.85	311.33 ± 1.31
2	303.13 ± 4.19	292.71 ± 1.92	297.92 ± 3.09	292.71 ± 1.92
4	273.96 ± 2.98	195.83 ± 4.47^a3	251.04 ± 4.68^a2	194.79 ± 1.92^a3
6	179.17 ± 3.09	123.96 ± 7.11^a3	148.96 ± 4.39^a2	117.71 ± 3.76^a3
8	142.71 ± 2.98	55.21 ± 2.98^a3	78.13 ± 2.68^a3	53.13 ± 2.68^a3
10	94.79 ± 2.98	18.75 ± 1.61^a3	38.54 ± 2.51^a3	18.75 ± 2.8^a3
12	64.58 ± 5.02	7.29 ± 3.76^a3	19.79 ± 1.92^a3	4.17 ± 3.09^a3
14	38.54 ± 4.39	0	4.17 ± 2.64^a3	0
16	23.96 ± 4.95	0	0	0

Note. Values are expressed as mean ± SEM (n = 6 mice in each group) and analyzed by one-way ANOVA followed by the post hoc Tukey test; ^acompared to the negative control; ^bcompared to the 5% CEO; ²; ³; SO = simple ointment; NF = nitrofurazone; CEO = crude flower extract ointment.