In Vivo Evaluation of Wound Healing and Anti-Inflammatory Activity of 80% Methanol Crude Flower Extract of Hagenia abyssinica (Bruce) J.F. Gmel in Mice

Table 8

Anti-inflammatory activity of the crude extract on carrageenan-induced paw edema.

Treatment group	The paw volume (ml), mean ± SEM
	Basal	1 h	2 h	3 h	4 h
Control	0.182 ± 0.01	0.180 ± 0.008	0.202 ± 0.014	0.203 ± 0.01	0.213 ± 0.008
Indomethacin	0.167 ± 0.008	0.137 ± 0.004^a2	0.107 ± 0.003^a3	0.088 ± 0.007^a3	0.070 ± 0.004^a3
100 mg/kg extract	0.195 ± 0.008	0.155 ± 0.008	0.150 ± 0.004^a2b2c2	0.117 ± 0.005^a3b1	0.100 ± 0.004^a3b2c1
200 mg/kg extract	0.193 ± 0.012	0.152 ± 0.008	0.128 ± 0.008^a3	0.100 ± 0.004^a3	0.085 ± 0.002^a3
400 mg/kg extract	0.178 ± 0.012	0.147 ± 0.005^a1	0.107 ± 0.004^a3	0.092 ± 0.005^a3	0.078 ± 0.005^a3

Note. Values are expressed as mean ± SEM (n = 6 mice in each group) and analyzed by one-way ANOVA followed by the post hoc Tukey test; ^acompared to the negative control; ^bcompared to indomethacin; ^ccompared to 400 mg/kg; ¹; ²; ³.