Evidence-Based Complementary and Alternative Medicine / 2020 / Article / Tab 3

Research Article

Synergistic Effect between Usnic Acid and Polymyxin B against Resistant Clinical Isolates of Pseudomonas aeruginosa

Table 3

Evaluation of usnic acid and polymyxin B interaction by the Checkerboard method.

Clinical isolatesMIC (μg/mL)MIC of the combination (μg/mL)FICIInteraction
Polymyxin BUsnic acidPolymyxin B + usnic acid

PA0545000.25/15.6250.094Synergism
PA0745000.25/15.6250.094Synergism
PA1885000.25/31.250.094Synergism
PA1945000.5/15.6250.156Synergism
PA46322500.25/7.81250.039Synergism
PA5682500.25/31.250.094Synergism
PA57325000.25/15.6250.039Synergism
PA78325000.25/15.6250.039Synergism
PA8242500.25/15.6250.125Synergism

MIC: minimum inhibitory concentration; FICI: fractional inhibitory concentration index.

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