Evaluation of Subchronic Toxicity and Genotoxicity of Ethanolic Extract of Aster glehni Leaves and Stems
Table 2
Urinalysis of male and female SD rats in the 13-week repeated oral toxicity study of EAG.
Tests
Result
EAG (mg/kg/day)
Male
Female
0
1,250
2,500
5,000
0
1,250
2,500
5,000
No. of animals examined
5
5
5
5
5
5
5
5
GLU
Negative
5
5
5
5
5
5
5
5
BIL
Negative
5
5
5
4
5
5
5
5
Small
0
0
0
1
0
0
0
0
KET
Negative
3
1
4
1
5
5
4
4
Trace
2
4
1
0
0
0
1
1
15
0
0
0
3
0
0
0
0
40
0
0
0
1
0
0
0
0
SG
≤1.005
1
0
0
0
5
1
1
0
1.010
4
2
4
2
0
3
2
3
1.015
0
2
1
2
0
1
1
1
1.020
0
1
0
1
0
0
1
1
pH
6.5
0
0
0
0
1
0
0
0
7.0
0
0
0
0
1
0
0
0
7.5
1
0
0
0
3
1
0
0
8.0
2
0
0
1
0
0
1
0
8.5
2
5
5
4
0
4
4
5
Volume (mL)
13.0 ± 4.6
11.6 ± 1.9
15.2 ± 1.1
11.4 ± 4.4
17.6 ± 5.5
10.8 ± 2.8
12.4 ± 4.6
8.8 ± 4.0
/Significant difference at / levels compared with the negative control by the Mann–Whitney U test. GLU, glucose (mg/dL); BIL, bilirubin (mg/dL); KET, ketone body (mg/dL); and SG, specific gravity.
