Evidence-Based Complementary and Alternative Medicine

Research Article

Evaluation of Subchronic Toxicity and Genotoxicity of Ethanolic Extract of Aster glehni Leaves and Stems

Table 4

Clinical biochemistry parameters of male and female SD rats in the 13-week repeated oral toxicity study of EAG.


Tests	EAG (mg/kg/day)
Tests	0	1,250	2,500	5,000

Male
AST (U/L)	83.7 ± 16.7	77.2 ± 14.9^a	82.6 ± 15.9	70.6 ± 6.6
ALT (U/L)	33.3 ± 5.8	32.6 ± 6.3^a	33.1 ± 4.1	31.8 ± 3.1
ALP (U/L)	88.1 ± 15.4	82.1 ± 16.0^a	89.8 ± 17.8	93.5 ± 18.0
CPK (U/L)	160.9 ± 80.9	173.8 ± 124.2^a	157.1 ± 94.7	118.0 ± 50.8
TBIL (mg/dL)	0.149 ± 0.030	0.145 ± 0.032^a	0.145 ± 0.020	0.145 ± 0.020
GLU (mg/dL)	155.0 ± 19.3	149.7 ± 14.8^a	151.1 ± 22.1	145.0 ± 17.0
TCHO (mg/dL)	89.0 ± 21.2	101.8 ± 21.3^a	101.4 ± 24.0	104.8 ± 24.2
TG (mg/dL)	56.3 ± 25.8	63.2 ± 26.2^a	60.6 ± 19.9	65.6 ± 28.2
TP (g/dL)	6.27 ± 0.16	6.37 ± 0.19^a	6.29 ± 0.29	6.30 ± 0.26
ALB (g/dL)	2.90 ± 0.07	2.95 ± 0.11^a	2.95 ± 0.11	2.93 ± 0.09
BUN (mg/dL)	13.9 ± 1.6	14.7 ± 1.1^a	14.4 ± 2.3	13.6 ± 1.9
CRE (mg/dL)	0.40 ± 0.03	0.39 ± 0.02^a	0.39 ± 0.02	0.40 ± 0.03

Female
AST (U/L)	70.1 ± 11.2	76.8 ± 13.8	76.4 ± 14.2	73.0 ± 18.0
ALT (U/L)	22.1 ± 3.5	24.1 ± 6.3	25.0 ± 4.6	25.5 ± 3.6
ALP (U/L)	43.5 ± 15.6	54.2 ± 14.1	46.8 ± 13.4	45.8 ± 11.1
CPK (U/L)	146.6 ± 126.3	126.4 ± 84.9	149.6 ± 94.6	128.1 ± 54.7
TBIL (mg/dL)	0.169 ± 0.024	0.190 ± 0.038	0.176 ± 0.020	0.174 ± 0.018
GLU (mg/dL)	121.4 ± 14.5	129.3 ± 16.1	122.7 ± 14.6	122.0 ± 10.7
TCHO (mg/dL)	86.2 ± 20.0	92.5 ± 8.5	100.5 ± 17.6	85.3 ± 10.9
TG (mg/dL)	35.6 ± 6.3	35.0 ± 4.7	36.3 ± 8.4	32.9 ± 8.4
TP (g/dL)	5.89 ± 0.26	6.11 ± 0.21	6.02 ± 0.20	5.97 ± 0.17
ALB (g/dL)	2.99 ± 0.13	3.11 ± 0.15	3.05 ± 0.11	3.12 ± 0.11
BUN (mg/dL)	15.8 ± 2.3	15.0 ± 1.3	15.0 ± 2.4	14.3 ± 1.2
CRE (mg/dL)	0.48 ± 0.04	0.47 ± 0.03	0.49 ± 0.06	0.46 ± 0.02

Data are expressed as mean ± standard deviation. ^aNumber of animals in group was 9; otherwise mean of 10 animals/sex/group. AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; CPK, creatine phosphokinase; TBIL, total bilirubin; GLU, glucose; TCHO, total cholesterol; TG, triglyceride; TP, total protein; ALB, albumin; BUN, blood urea nitrogen; and CRE, creatinine.