Exploring the Potential Mechanism of Tang-Shen-Ning Decoction against Diabetic Nephropathy Based on the Combination of Network Pharmacology and Experimental Validation

Table 2

The information of 23 TSN-related DN-DEGs.

Gene	Description	Log FC	value	Regulation
LPL	Lipoprotein lipase	−3.19928	7.54E − 07	Downregulated
IGF1	Insulin-like growth factor 1	−2.57456	7.11E − 05	Downregulated
GPRC5A	G protein-coupled receptor class C group 5 member A	−2.27982	3.09E − 07	Downregulated
PLAT	Tissue-type plasminogen activator	−2.24543	0.000584	Downregulated
SNCA	Synuclein alpha	−2.1809	1.15E − 06	Downregulated
F3	Tissue factor	−2.14994	8.01E − 06	Downregulated
HPGD	15-Hydroxyprostaglandin dehydrogenase (NAD(+))	−2.06642	0.000075	Downregulated
CTGF	CCN family member 2	−1.98966	2.17E − 05	Downregulated
GJA1	Gap junction alpha-1 protein	−1.93855	3.39E − 08	Downregulated
BMP2	Bone morphogenetic protein 2	−1.82795	4.52E − 05	Downregulated
ALB	Albumin	−1.78623	0.00896	Downregulated
CLDN5	Claudin 5	−1.75802	5.85E − 06	Downregulated
GADD45B	Growth arrest and DNA damage inducible beta	−1.65127	2.25E − 05	Downregulated
VEGFA	Vascular endothelial growth factor A	−1.58624	5.92E − 07	Downregulated
LYZ	Lysozyme	1.529532	0.00258	Upregulated
IRF8	Interferon regulatory factor 8	1.583247	0.000131	Upregulated
ALOX5	Arachidonate 5-lipoxygenase	1.673735	0.00516	Upregulated
LCK	Tyrosine-protein kinase lck	1.694745	2.47E − 06	Upregulated
AKR1B10	Aldo-keto reductase family 1 member B10	1.705447	0.00508	Upregulated
CCL5	C-C motif chemokine receptor 5	1.720493	0.000615	Upregulated
MOXD1	Monooxygenase 1	1.905562	1.47E − 05	Upregulated
MMP7	Matrix metallopeptidase 7	2.08645	0.000339	Upregulated
ADH1B	Alcohol dehydrogenase 1B	2.183966	2.28E − 05	Upregulated