In Vivo Antimalarial Activity and Toxicity Study of Extracts of Tagetes erecta L. and Synedrella nodiflora (L.) Gaertn. from the Asteraceae Family

Table 1

Effects of aqueous extract of T. erecta and ethanolic extract of S. nodiflora against Plasmodium parasites in malaria-infected mice.

Group	Dose (mg/kg)	iRBCs	% parasitemia	% suppression
Negative control	—	7.50 ± 1.91	64.25 ± 0.57^b,c,d,e,f,g,h	—
Artesunate	6	192.75 ± 1.71	3.64 ± 0.59^a,c,d,e,f,g,h	95.82 ± 2.71^c,d,e,f,g,h
T. erecta extract	200	142.00 ± 2.92	47.33 ± 0.97^a,b,d,e	26.33 ± 1.51^b,d,e
	400	94.80 ± 3.27	31.60 ± 0.98^a,b,c,e	50.82 ± 1.52^b,c,e
	600	66.20 ± 1.48	22.07 ± 0.49^a,b,c,d	65.65 ± 0.77^b,c,d
S. nodiflora extract	200	118.40 ± 3.51	39.47 ± 1.17^a,b,g,h	38.57 ± 1.82^b,g,h
	400	81.60 ± 6.11	27.20 ± 2.04^a,b,f,h	57.67 ± 3.17^b,f,h
	600	72.00 ± 3.61	24.00 ± 1.20^a,b,f,g	62.65 ± 1.87^b,f,g

The data are presented as the means ± SEMs (n = 5 per group), . iRBCs: the number of infected red blood cells per field; the total number of RBCs per field was 300. ^aCompared with the negative control, ^bcompared with artesunate, ^ccompared with the 200 mg/kg T. erecta extract, ^dcompared with the 400 mg/kg T. erecta extract, ^ecompared with the 600 mg/kg T. erecta extract, ^fcompared with the 200 mg/kg S. nodiflora extract, ^gcompared with the 400 mg/kg S. nodiflora extract, and ^hcompared with the 600 mg/kg S. nodiflora extract.