Trefoil Factor 3 Inhibits Thyroid Cancer Cell Progression Related to IL-6/JAK/STAT3 Signaling Pathway

Figure 1

TFF3 is underexpressed in thyroid cancer cell lines and tumors. (a) The expression of TFF3 in thyroid cancer tissues (n = 505) and the normal tissues (n = 59) analyzed by UALCAN based on the TCGA database. (b) The expression of TFF3 in normal tissues (n = 59) and thyroid cancer stage 1 (n = 284), stage 2 (n = 52), stage 3 (n = 112), and stage 4 tissues (n = 55) analyzed by UALCAN based on the TCGA database. (c) TFF3 expression level in thyroid cancer nodal metastasis N0 and N1 tissues and the normal tissues analyzed by UALCAN based on the TCGA database. (d) GEPIA analysis of disease-free survival of TFF3. (e) RT-PCR analysis of the expression level of TFF3 in 5 cancerous cell lines, FTC133, BCPAP, TPC-1, 8505C, and SW579, and a normal thyroid cell line Nthy-ori 3-1. (f) Western blot analysis of the expression level of TFF3 in 5 cancerous cell lines, FTC133, BCPAP, TPC-1, 8505C, and SW579, and a normal thyroid cell line Nthy-ori 3-1. and vs. Nthy-ori 3-1.

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