Evidence-Based Complementary and Alternative Medicine / 2021 / Article / Tab 2 / Research Article
Identification of Potential Biomarkers of Depression and Network Pharmacology Approach to Investigate the Mechanism of Key Genes and Therapeutic Traditional Chinese Medicine in the Treatment of Depression Target PDB ID Compound Affinity (kJ·mol−1 ) JUN P05412 Luteolin −8.8 Quercetin −8.6 Kaempferol −8.4 Beta-sitosterol −6.8 MAPK8 P45983 Kaempferol −5.5 RELA P9WHG9 Isorhamnetin −7.6 Quercetin −7.5 Arachidonic acid −5 TP53 Q96S44 Luteolin −8.2 Quercetin −8 RB1 P13405 Quercetin −8.4 Luteolin −8.9 MAPK14 Q16539 Petunidin −9 Isorhamnetin −9 CCND1 P24385 Quercetin −7.1 Arachidonic acid −4.9 Luteolin −7.3 MAPK1 P28482 Quercetin -8.4 Arachidonic acid −5.8 Luteolin −8.5 AKT1 P31750 Luteolin −6.3 Quercetin −6.3 Kaempferol −6.4 HSP90AA1 P07900 Kaempferol −6.7 Beta-sitosterol −7.4 (+)-Catechin −6.8 Isorhamnetin −6.9 Cubebin −6.7 Quercetin −6.9 ESR1 P03372 (+)-Catechin −7.1 Isorhamnetin −8.5