Network Pharmacology and Molecular Docking Study of Zhishi-Baizhu Herb Pair in the Treatment of Gastric Cancer

Table 4

The binding energies of top 20 key target proteins with luteolin and naringenin.

Target	PDB ID	Luteolin (kcal/mol)	Naringenin (kcal/mol)
AKT1	4gah	−7.45	−6.18
EGFR	4qvx	−6.42	−5.83
IL-6	6 mg^3	−6.86	−5.51
VEGFA	6v7k	−6.03	−6.63
MAPK3	4qtb	−6.52	−5.2
CASP3	4jqy	−6.16	−6.07
JUN	3v3v	−6.2	−6.06
STAT3	6smb	−7.01	−5.05
CCND1	2w9f	−6.84	−5.86
MAPK8	3o2m	−5.77	−5.04
ERBB2	4hrn	−5.1	−5.41
ESR1	1a52	−5.42	−5.77
MMP9	1l6j	−6.78	−6.45
PTGS2	5ikr	−6.36	−5.8
MAPK14	5omh	−7.03	−6.77
BCL2L1	4qvx	−7.59	−7.41
MTOR	3qar	−6.36	−5.35
CREB1	1ci6	−4.21	−4.39
MMP2	1rtg	−6.67	−6.06
MDM2	3lbk	−5.78	−5.79