Anti-Inflammatory Effects of Lagerstroemia ovalifolia Teijsm. & Binn. in TNFα/IFNγ-Stimulated Keratinocytes

Figure 7

Schematic diagram illustrating the mechanisms underlying the anti-inflammatory effects of LOC. LOC, Lagerstroemia ovalifolia CHCl₃ fraction 5 extract; TNFα, tumour necrosis factor-α; IFNγ, interferon gamma; NF-κB, nuclear factor-κB; IκBα, inhibitor of NF-κB; Ub, ubiquitination; JAK1, Janus kinase 1; JAK2, Janus kinase 2; STAT1, signal transducer and activator of transcription 1; PI3K, phosphoinositide 3-kinase; AKT, protein kinase B (PKB); TARC/CCL17, thymus and activation-regulated chemokine; MDC/CCL22, macrophage-derived chemokine; IL-8, interleukin-8; IL-1β, interleukin-1 beta; IL-6, interleukin-6; and MCP-1, monocyte chemoattractant protein-1.