Synergistic Protective Effect of Curcumin and Resveratrol against Oxidative Stress in Endothelial EAhy926 Cells

Figure 8

Antioxidant and protective effects of C and R in EAhy926 cells against oxidative stress in vitro. H₂O₂ stimulates the ROS which then triggers the Nrf2 release and translocation, which initiates the activation of HO-1, upregulation of NAD⁺ pool, and SOD activity. In EAhy926 cells, C and R both inhibited the ROS expression and increased Nrf2 and HO-1 protein expressions. The combined effect has led to a further promoted inhibition of ROS and increased expression of Nrf2, HO-1, NAD+, and SOD and consequently resulted in a higher survival rate of endothelial cells against the impairment of oxidative stress.