The Application of Citrus folium in Breast Cancer and the Mechanism of Its Main Component Nobiletin: A Systematic Review

Table 1

The syndrome of BC in TCM.

Syndromes	Symptoms	Tongue and pulse	Main symptoms	Stage
Disharmony of the thoroughfare vessel (Chong channels) and conception vessel (Ren channels)	Menstrual changes, lassitude, tidal fever and night sweating, soreness and weakness of the waist and knees, irritability, dry mouth, anorexia, dizziness	Light color of the tongue, thin fur, wiry pulse, thread pulse	Menstrual changes, tidal fever and night sweating, dry mouth	I
Stagnation of liver qi	Depression, hypochondrium distending pain, soreness and weakness of the waist and knees, menstrual changes	Reddish tongue, thin fur, wiry pulse, thread pulse	Hypochondrium distending pain, depression	I
Vital qi insufficiency and heat flourishing	Irritability, menstrual changes, lassitude, anorexia, soreness and weakness of the waist and knees, insomnia	Light color of the tongue, yellow and greasy fur, wiry pulse, thread pulse, weak pulse	Lassitude, tidal fever, yellow fur	II
Qi and Yin deficiency	Lassitude, depression, menstrual changes, anorexia, tidal fever and night sweating, dry and itchy throat, insomnia	Light color of the tongue, wiry pulse, thread pulse	Lassitude, tidal fever, and night sweating	III; IV
Yin deficiency of the liver and kidney	Lassitude, soreness, and weakness of the waist and knees, insomnia, dizziness, dry and itchy throat, tidal fever and night sweating, tinnitus, forgetfulness	Reddish tongue, thin fur, wiry pulse, thread pulse	Soreness and weakness of the waist and knees, insomnia, tidal fever, tinnitus	III; IV