Review Article

The Application of Citrus folium in Breast Cancer and the Mechanism of Its Main Component Nobiletin: A Systematic Review

Table 2

The summary of Citrus folium treating breast-related diseases.

SourcePrescriptionCompositionName of the diseaseSyndrome typeReferences

Experience Gained in Treating External Diseases (Yang Ke Xin de Ji, Qing Dynasty, AD 1805)Citrus folium decoctionCitrus folium, Taraxaci cum radice herba, Fritillariae thunberii bulbus, Prunellae vulgaris spica, Citri reticulatae viride pericarpium, Angelicae sinensis corpus Radicis, Paeoniae rubrae radix, Trichosanthis kirilowii radix, Cyperi rotundi rhizoma, Scutellariae baicalensis radixBreast carbuncleHeat flourishing, liver-qi stagnation[74]

Wonders of Effective Prescription (Qi Xiao Liang Fang, Ming Dynasty, AD 1520)Forsythia suspense decoctionCitrus folium, Forsythia suspense Fructus, Liguszici, Trichosanthis semen, Gleditsiae Sinensis Spina, Citri reticulate viride pericarpium, Glycyrrhizae uralensis praparatae radix, Persicae semenBreast carbuncle
Mammary node
Phlegm and blood stasis, liver-qi stagnation[75]

Feng’s Ace-Pack (Feng Shi Jin Nang, Qing Dynasty, AD 1722)Citrus forsythia decoctionCitrus folium, Citri reticulate viride pericarpium, Trichosanthis Fructus, Forsythia suspense Fructus, Persicae semen, Gleditsiae Sinensis Spina, Bulpleuri radix, Glycyrrhizae ureagenesis radixBreast carbuncleHeat flaming in the beginning[76]

Integration of Medicine (Yi Xue Ji Cheng, Qing Dynasty, AD 1873)Dissipating nodules’ decoctionCitrus folium, Taraxaci cum radice herba, Cyperi rotundi rhizoma, Liguszici, Angelicae dahuricae radix, Fritillariae thunberii bulbus, Lonicerae japonicae flos, Perillae frutescentis folium, Alli fistulosi bulbusMammary nodeHeat flourishing, liver-qi stagnation[77]

Bamboo Women’s Treatment (Zhu Lin Nv Ke Zheng Zhi, Qing Dynasty, AD 1817)Lonicerae japonicae flos decoctionCitrus folium, Lonicerae japonicae flos, Astragali membranacei radix, Angelicae sinensis corpus radicis, Glycyrrhizae uralenisis radixBreast cancerVital qi deficiency and heat-induced toxicity[73]

Orthodox Manual of External Medicine (Wai Ke Zheng Zong, Ming Dynasty, AD 1617)Citrus folium powderCitrus folium, Bulpleuri radix, Citri reticulate pericarpium, Liguszici, Gardeniae jasminoidis Fructus, Citri reticulate viride pericarpium, Gypsum, Scutellariae baicalensis radix, Forsythia suspense Fructus, Glycyrrhizae uralensis praparatae radixBreast cancerHeat flourishing, liver-qi stagnation[54]