Review Article
Herbal Medicines Targeting the Improved β-Cell Functions and β-Cell Regeneration for the Management of Diabetes Mellitus
Table 1
Investigations on experimental drugs derived from plant sources for their ability to improve β-cell regeneration.
| Experimental drug | Experimental system | Dose | β-Cell regeneration mechanism | Reference |
| Harmine | C57B6 mice with partial pancreatectomy and human islet transplantation | 10 mg/kg | β-Cell proliferation | [14] | Rat insulinoma (Ins1 823/13) and human hepatoma (HepG2) cell lines | 1–15 μM | β-Cell proliferation | |
| γ-Aminobutyric acid | Wild-type transgenic mice induced with streptozotocin (60 mg/kg) | 250 μg/kg | β-Cell regeneration via differentiation of α-cells to β-cells | [16] |
| Artemether | Mouse β-cell line (Min6) induced with doxycycline (1 μg/mL) for overexpression of ARX transcription factor | 10 μM | ARX repression thereby increase β-cell turnover and conversion of α-cells to β-cells | [17] | Zebrafish larvae induced with dimerizer AP20187 (2 μM) | 5 μM | β-Cell proliferation and conversion of α-cells to β-cells | | Sprague–Dawley rats induced with streptozotocin (60 mg/kg) | 20–200 mg/kg | β-Cell proliferation and conversion of α-cells to β-cells | |
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