Genetic and Functional Evaluation of the Role of FOXO1 in Antituberculosis Drug-Induced Hepatotoxicity

Figure 2

Effects of INH/RIF on the mRNA level of ALAS1 and FOXO1 in L-02 cells and HepG2 cells. (a) L-02 cells were treated without the drug as the blank control, with INH (600 μM), RIF (200 μM), or INH/RIF (600/200 μM) for 24 h. ALAS1 mRNA expression levels were analysed by RT-PCR. (b) HepG2 cells were treated without the drug, with INH (600 μM), RIF (200 μM), or INH/RIF (600/200 μM) for 24 h. ALAS1 mRNA expression levels were analysed by RT-PCR. (c) L-02 cells were treated with the same concentration of INH and/or RIF for 24 h. FOXO1 mRNA expression levels were analysed by RT-PCR. (d) HepG2 cells were treated with the same concentration of INH and/or RIF for 24 h. FOXO1 mRNA expression levels were analysed by RT-PCR.

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