Genetic and Functional Evaluation of the Role of FOXO1 in Antituberculosis Drug-Induced Hepatotoxicity

Table 2

Genetic models of SNPs related to ATDH in patients with tuberculosis.

Gene	dbSNP	Dominant model		Recessive model		Additive model
		OR (95% CI)		OR (95% CI)		OR (95% CI)
ALAS1	rs353556	1.067 (0.683–1.666)	0.775	1.273 (0.802–2.020)	0.802	1.121 (0.843–1.488)	0.431
	rs3852071	0.733 (0.466–1.154)	0.180	0.328 (0.043–2.503)	0.043	0.724 (0.477–1.098)	0.128
	rs352169	1.130 (0.752–1.697)	0.556	1.251 (0.709–2.208)	0.709	1.129 (0.842–1.512)	0.417
FOXO1	rs2755237	0.631 (0.423–0.942)	0.024	0.517 (0.181–1.476)	0.181	0.658 (0.464–0.932)	0.018
	rs2701891	1.176 (0.793–1.744)	0.418	1.727 (0.896–3.328)	0.896	1.226 (0.906–1.660)	0.186
	rs3751436	1.181 (0.775–1.798)	0.437	1.187 (0.683–2.063)	0.683	1.139 (0.849–1.529)	0.384
	rs4435111	0.572 (0.372–0.879)	0.010	0.359 (0.084–1.526)	0.084	0.591 (0.401–0.869)	0.007
	rs7325594	1.432 (0.924–2.219)	0.107	1.196 (0.688–2.080)	0.688	1.255 (0.931–1.691)	0.135

: the value was calculated using the logistic regression method. “1” = mutant allele; “2” = wild-type allele; “11” = mutant homozygote; “12” = heterozygote; “22” = wild-type homozygote.