Tanshinone IIa Induces Autophagy and Apoptosis via PI3K/Akt/mTOR Axis in Acute Promyelocytic Leukemia NB4 Cells

Figure 1

TanIIa inhibited NB4 viability and proliferation. (a) The chemical structure of TanIIa. (b) Cell viability assay: relative cell viability analyzed by CCK-8 in NB4 cells treated with different TanIIa doses, namely, 0, 1, 2, 4, 8, 16, 32, 64, 128, and 256 µmol/L for 24 h. Data were expressed as the mean ± SD of three independent experiments. (c) Cell proliferation assay: the relative cell number analyzed by CCK-8 in NB4 cells treated with TanIIa for 0–72 h. Data were expressed as the mean ± SD of three independent experiments.

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