RNA-Seq Expression Analysis of Chronic Asthmatic Mice with Bu-Shen-Yi-Qi Formula Treatment and Prediction of Regulated Gene Targets of Anti-Airway Remodeling
Table 2
Differently expressed gene with FC > (±) 2.0 in asthma group (M) relative to treatment group (T) related to inflammatory, oxidative stress, mitochondria, PI3K/AKT, and MAPK signal pathways.
Gene name
Description
log2 fold change (A vs T)
Adipoq
Adiponectin C1Q and collagen domain containing
5.80
Nefm
Neurofilament medium polypeptide
5.46
Car3
Carbonic anhydrase 3
5.10
Mb
Myoglobin
3.94
Krt15
Keratin 15
3.99
Cyp2e1
Cytochrome P450 family 2 subfamily e polypeptide 1
3.71
Gdap1
Ganglioside induced differentiation associated protein 1
3.66
Cyp4a12b
Cytochrome P450 family 4 subfamily a polypeptide 12B
3.10
Cacna2d2
Calcium channel voltage dependent alpha 2 delta subunit 2
2.77
Mpo
Myeloperoxidase
2.77
Ckmt2
Creatine kinase mitochondrial 2
2.75
Erbb4
Erb-B2 receptor tyrosine kinase 4
2.63
Mapk10
Mitogen-activated protein kinase 10
2.47
Pln
Phospholamban
2.42
Obscn
Obscurin cytoskeletal calmodulin and titin interacting RhoGEF