RNA-Seq Expression Analysis of Chronic Asthmatic Mice with Bu-Shen-Yi-Qi Formula Treatment and Prediction of Regulated Gene Targets of Anti-Airway Remodeling

Table 2

Differently expressed gene with FC > (±) 2.0 in asthma group (M) relative to treatment group (T) related to inflammatory, oxidative stress, mitochondria, PI3K/AKT, and MAPK signal pathways.

Gene name	Description	log2 fold change (A vs T)
Adipoq	Adiponectin C1Q and collagen domain containing	5.80
Nefm	Neurofilament medium polypeptide	5.46
Car3	Carbonic anhydrase 3	5.10
Mb	Myoglobin	3.94
Krt15	Keratin 15	3.99
Cyp2e1	Cytochrome P450 family 2 subfamily e polypeptide 1	3.71
Gdap1	Ganglioside induced differentiation associated protein 1	3.66
Cyp4a12b	Cytochrome P450 family 4 subfamily a polypeptide 12B	3.10
Cacna2d2	Calcium channel voltage dependent alpha 2 delta subunit 2	2.77
Mpo	Myeloperoxidase	2.77
Ckmt2	Creatine kinase mitochondrial 2	2.75
Erbb4	Erb-B2 receptor tyrosine kinase 4	2.63
Mapk10	Mitogen-activated protein kinase 10	2.47
Pln	Phospholamban	2.42
Obscn	Obscurin cytoskeletal calmodulin and titin interacting RhoGEF	2.24
Cox8b	Cytochrome c oxidase subunit VIIIb	2.23
Col9a1	Collagen type IX alpha 1	−4.69
Mt-Nd4l	Mitochondrially encoded NADH dehydrogenase 4L	−2.94
Hmox1	Heme oxygenase 1	−2.48
Tnc	Tenascin C	−2.16
Spp1	Secreted phosphoprotein 1	−2.02