Research Article
Network Pharmacology Study on Molecular Mechanisms of Zhishi Xiebai Guizhi Decoction in the Treatment of Coronary Heart Disease
Table 1
Effective components of Zhishi Xiebai Guizhi Decoction that meet the demands of both OB ≥ 30% and DL ≥ 0.18 were obtained from TCMSP.
| Drug | ID | Components | OB% | DL |
| GL | MOL001494 | Mandenol | 41.9962 | 0.19321 | MOL002881 | Diosmetin | 31.13795 | 0.27442 | MOL004355 | Spinasterol | 42.97937 | 0.75534 | MOL005530 | Hydroxygenkwanin | 36.467 | 0.27206 | MOL006756 | Schottenol | 37.42312 | 0.75067 | MOL007165 | 10α-cucurbita-5,24-diene-3β-ol | 44.01594 | 0.7445 | MOL007171 | 5-Dehydrokarounidiol | 30.22665 | 0.7703 | MOL007172 | 7-Oxo-dihydrokaro-unidiol | 36.85021 | 0.75387 | MOL007175 | Karounidiol 3-o-benzoate | 43.99061 | 0.49505 | MOL007179 | Linolenic acid ethyl ester | 46.10096 | 0.19694 | MOL007180 | Vitamin-e | 32.28643 | 0.69563 |
| HP | MOL005970 | Eucalyptol | 60.62476 | 0.32159 | MOL005980 | Neohesperidin | 57.44074 | 0.27085 |
| GZ | MOL000073 | Ent-epicatechin | 48.95984 | 0.24162 | MOL000358 | Beta-sitosterol | 36.91391 | 0.75123 | MOL000359 | Sitosterol | 36.91391 | 0.7512 | MOL000492 | (+)-catechin | 54.82643 | 0.24164 | MOL001736 | (−)-Taxifolin | 60.50622 | 0.27342 |
| XB | MOL000098 | Quercetin | 46.43335 | 0.27525 | MOL000332 | n-coumaroyltyramine | 85.62883 | 0.20287 | MOL000358 | Beta-sitosterol | 36.91391 | 0.75123 | MOL000483 | (Z)-3-(4-Hydroxy-3-methoxy-phenyl)-N-[2-(4-hydroxyphenyl) ethyl] acrylamide | 118.3477 | 0.26399 | MOL000631 | Coumaroyltyramine | 112.9016 | 0.20234 | MOL001973 | Sitosteryl acetate | 40.38964 | 0.85102 | MOL002341 | Hesperetin | 70.31209 | 0.27252 | MOL004328 | Naringenin | 59.2939 | 0.21128 | MOL007640 | Macrostemonoside e_qt | 35.259 | 0.87216 | MOL007650 | PGA (sup 1) | 43.98251 | 0.25437 | MOL007651 | Prostaglandin B1 | 40.20777 | 0.25384 |
| ZS | MOL000006 | Luteolin | 36.16263 | 0.24552 | MOL001798 | Neohesperidin_qt | 71.16886 | 0.27085 | MOL001803 | Sinensetin | 50.55685 | 0.44634 | MOL001941 | Ammidin | 34.54856 | 0.22355 | MOL002914 | Eriodyctiol (flavanone) | 41.35043 | 0.2436 | MOL004328 | Naringenin | 59.2939 | 0.21128 | MOL005100 | 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl) chroman-4-one | 47.73644 | 0.27226 | MOL005828 | Nobiletin | 61.66944 | 0.51652 | MOL005849 | Didymin | 38.55139 | 0.23908 | MOL007879 | Tetramethoxyluteolin | 43.68476 | 0.37009 | MOL009053 | 4-[(2S,3R)-5-[(E)-3-Hydroxyprop-1-enyl]-7-methoxy-3-methylol-2,3-dihydrobenzofuran-2-yl]-2-methoxy-phenol | 50.75514 | 0.3948 | MOL013276 | Poncirin | 36.54601 | 0.74202 | MOL013277 | Isosinensetin | 51.15169 | 0.44149 | MOL013279 | 5,7,4′-Trimethylapigenin | 39.83272 | 0.29636 | MOL013352 | Obacunone | 43.28625 | 0.76724 | MOL013428 | Isosakuranetin-7-rutinoside | 41.24013 | 0.71616 | MOL013430 | Prangenin | 43.59734 | 0.29428 | MOL013433 | Prangenin hydrate | 72.63401 | 0.28863 | MOL013435 | Poncimarin | 63.62093 | 0.34942 | MOL013436 | Isoponcimarin | 63.2776 | 0.31316 | MOL013437 | 6-Methoxy aurapten | 31.23777 | 0.3008 | MOL013440 | Citrusin B | 40.79717 | 0.71331 |
|
|