Evaluation of Antidiarrheal Activity of 80% Methanolic Extract of the Leaves of Cordia africana (Lamiaceae) in Mice

Table 3

Effect of crude extract of the leaves of Cordia africana on gastrointestinal transit in mice.

Dose (mg/kg)	Length of the small intestine (cm)	Distance travelled by charcoal meal (cm)	Peristaltic index (%)	% Inhibition
Control	51 ± 0.97	44.5 ± 0.76	87.3 ± 1.51	—
80ME 100	52.2 ± 1.08	42.7 ± 0.95	83.7 ± 1.18	4.1
80ME 200	50.2 ± 1.08	23.3 ± 0.49^b	46.6 ± 1.38^b	47.6
80ME 400	48.5 ± 1.69	13.0 ± 0.97^b	26.6 ± 1.23^b	70.8
Loperamide 3	51.8 ± 1.30	12.7 ± 0.72^b	24.5 ± 1.57^b	71.5

Values are expressed as mean ± standard error of the mean (n = 6); analysis was done using one-way analysis of variance followed by Tukey post hoc test. ^bCompared with negative control values. ME = methanol extract; cm = centimeter. .