Evaluation of Antidiarrheal Activity of 80% Methanolic Extract of the Leaves of Cordia africana (Lamiaceae) in Mice

Table 4

Effect of crude extract of the leaves of Cordia africana on intestinal fluid accumulation in mice.

Dose (mg/kg)	Volume of intestinal content (ml)	% Inhibition	Weight of intestinal content (gm)	% Inhibition
Control	1.30 ± 0.10	—	1.50 ± 0.09	—
80ME 100	1.16 ± 0.11	10.8	1.17 ± 0.07	22
80ME 200	0.75 ± 0.08^b	42.3	0.85 ± 0.08^b	43.3
80ME 400	0.50 ± 0.10^b	61.5	0.73 ± 0.15^b	51.3
Loperamide 3	0.42 ± 0.06^b	67.7	0.70 ± 0.06^b	53.3

Values are expressed as mean ± standard error of the mean (n = 6); analysis was done using one-way analysis of variance followed by Tukey post hoc test. ^bCompared with negative control values. ME = methanol extract; ml = millimeter; gm = gram. ; .