Saireito Improves Lymphatic Function and Prevents UVB-Induced Acute Inflammation and Photodamage in HR-1 Hairless Mice

Figure 5

Effect of SRT on UVB-induced structural change in blood vessels and PGE2 contents. (a) Skin sections were collected at 72 h after irradiation, and immunohistochemical staining was performed for the blood vessel marker Meca-32. Scale bar = 200 μm. (b) UVB irradiation increased the blood vessel size from 24 h to 72 h after irradiation, and SRT had no effect on dilation. (c) UVB irradiation and SRT treatment had no effect on blood vessel density. (d) PGE2 expression significantly increased at 24 h and 48 h after irradiation, and SRT had no effect on the UVB-induced upregulation of PGE2. Data were expressed as mean ± SEM (n = 4-5). and vs. control, Dunnett’s test. SRT: Saireito extract; UVB: ultraviolet B; PGE2: prostaglandin E2.

(a)

(b)

(c)

(d)