|
| Terpenoid natural TCM small molecules | Experimental model | Dose/concentration | Mechanism of action | Ref. |
|
| Essential oil of curcuma zedoaria (EO-CZ) | B16BL6 and SMMC-7721 cells; | EO-CZ (0, 5, 10, 20, 40, 80, and 120 μM/ml) for 48 h | Inhibit B16BL6 and SMMC-7721 cell proliferation; | [62] |
| HUVEC (human umbilical vein endothelial cells); | Inhibited CD34, MMP-2, and MMP-9; |
| Sprout vessels of Sprague-Dawley male rat aortic ring; |
| Andrographis (Andro) | A549 NSCLC cells; | Andro (0, 1.0, 2.5, and 5.0 µM) for 24 h | Inhibited the migration and invasion of A549 cells; | [63] |
| Inhibited MMP-7 but not MMP-2 or MMP-9; |
| Suppressed on PI3K/Akt/AP-1 signaling pathway; |
| Dehydrocostus lactone (DL) | Temperature-sensitive rat lymphatic endothelial (TR-LE) cells; | DL (0.01, 0.1, and 0.5 µM) for 0, 6, 12, 24, or 48 h | Inhibition of the proliferation of TR-LE cells; | [67] |
| Oridonin | H1688 SCLC cells; | Oridonin (0, 2.5, 5, 10, 20, and 40 µM) for 24 or 48 h | Inhibited cell migration; | [69] |
| BEAS‐2B and HBE cells; | Not-affected cell proliferation and apoptosis; |
| Triptolide (TP) | A549 NSCLC cells; | TP 10 nM for 48 h | Decreased migration and invasion of lung cancer cells; | [70] |
| H460 and H358 cells; |
| Triptolide (TP) | A549 NSCLC cells; | TP (1, 2, 4, 8, 16, and 32 ng/ml) f or 24, 36, or 48 h | Inhibited the migration and invasion of A549; | [71] |
| Upregulated E-cadherin protein expression; |
| Downregulated the MMP9, Snail, and vimentin expression levels; |
| Astagaloside IV (AS-IV) | A549 NSCLC cells. | AS-IV (0, 5, 10, and 20 μM) for 24 h | Inhibited the migration and invasion of A549; | [73] |
| Decreased the levels of MMP-2, MMP-9, integrin β1, TGF-β1, TNF-α, and IL-6 levels; |
| Related to the PKC-α-ERK1/2-NF-κB pathway. |
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