Methanolic Extract of Myrsine africana Leaf Ameliorates Hyperglycemia and Dyslipidemia in Alloxan-Induced Diabetic Albino Mice
Table 9
Effect of M. africana methanolic leaf extract on glycated hemoglobin, insulin, and carbohydrate metabolizing enzymes in diabetic mice.
Groups
Biochemical parameters
HbA1c (%)
Insulin (µU/ml)
Hexokinase (µg/mg of tissue)
Glucose-6-phosphatase (unit/mg of tissue)
Fructose-1-6-bisphosphatase (unit/mg of tissue)
Diabetic control
4.8 ± 0.18 π
3.6 ± 0.06 π
90.58 ± 2.06 π
14.2 ± 0.23 π
55.38 ± 0.27 π
MA 250 mg/kg
3.5 ± 0.09 α
6.8 ± 0.05 α
116.82 ± 1.85 α
13.7 ± 0.36 α
43.5 ± 0.43 α
MA 500 mg/kg
2.9 ± 0.05 α
10.4 ± 0.17 α
132.12 ± 1.52 α
11.5 ± 0.19 α
38.34 ± 0.52 α
MA 1000 mg/kg
2 ± 0.02 α
12.6 ± 0.09 α
142.73 ± 1.54 α
9.8 ± 0.03 α
31.94 ± 0.48 α
GLC 5 mg/kg
2.1 ± 0.06 α
13.4 ± 0.27 α
145.79 ± 0.63 α
8.6 ± 0.14 α
30.55 ± 0.8 α
Normal control
1.2 ± 0.15
14.6 ± 0.25
148.25 ± 1.51
9 ± 0.15
28.39 ± 0.55
Values are expressed as mean ± SD; n = 6; π compared with normal control; α compared with diabetic control; ∗P,∗∗P,∗∗∗P; HbA1c, glycated hemoglobin; MA, Myrsine africana leaf extract.
