Zingiberensis Newsaponin Inhibits the Malignant Progression of Hepatocellular Carcinoma via Suppressing Autophagy Moderated by the AKR1C1-Mediated JAK2/STAT3 Pathway

Figure 5

ZnS inhibits the expression of autophagy-related proteins in HCC cells. (a) The expression of LC3 in Huh7 and SMMC7721 cells measured using immunofluorescence staining. (b) The relative expression of LC3II/LC3I and P62 examined by Western blot. Cells were treated with 0.5 µM ZnS for Huh7 and 1.0 µM for SMMC7721 cells and/or 10 mM 3-methyladenine (3-MA) for 48 h.  < 0.001 vs. the control group.  < 0.001 vs. the ZnS + 3-MA group.

(a)

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