Research Article
Herbal Prescription SH003 Alleviates Docetaxel-Induced Neuropathic Pain in C57BL/6 Mice
Figure 3
Effect of SH003 administration on docetaxel-induced mechanical allodynia in C57BL/6 mice. The mice were divided into Control (n = 5), Docetaxel (n = 5), and Docetaxel + SH003 (n = 5) groups. Docetaxel was intravenously injected via tail vein of C57BL/6 mice on the 1st day, and mechanical allodynia threshold by von Frey filament was followed up. From 3rd day, SH003 was orally administered at least 60 min before the performance of mechanical allodynia test. Mean mechanical threshold (a) and body weight (b). Data are presented as mean ± SEM. The differences of means between the groups were analyzed by two-way ANOVA using Sidak’s multiple comparisons test (, Docetaxel vs. Control; , Docetaxel vs. Control; , Docetaxel + SH003 vs. Docetaxel; , Docetaxel + SH003 vs. Docetaxel).
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