Evidence-Based Complementary and Alternative Medicine / 2021 / Article / Tab 1 / Review Article
Flaxseed Oil Supplementation Augments Antioxidant Capacity and Alleviates Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Table 1 Study characteristics of included studies.
Citation (first author et al., year) Location Study population Sample size (control/intervention) Mean age (control/intervention) Intervention/daily dose Duration (week) Measured outcomes and results Pilar et al., 2014 Brazil MetS 24/20 45–55/45–55 Golden flaxseed/40 g 4 MDA (↓ ) Mirfatahi et al., 2016 Iran HD 17/17 59.0 ± 16.4/68.0 ± 12.3 Flaxseed oil/6 g 8 MDA (Ns) Soleimani et al., 2017 Iran DN 30/30 62.4 ± 9.6/62.9 ± 10.5 Omega-3 fatty acids from flaxseed oil/1000 mg 12 TAC (↑ ), MDA (Ns), GSH (Ns) Soleimani et al., 2017 Iran DFU 30/30 59.9 ± 9.2/58.8 ± 11.2 Omega-3 fatty acids from flaxseed oil/2000 mg 5 TAC (↑ ), MDA (Ns), GSH (↑ ) Akrami et al., 2017 Iran MetS 26/26 48.8 ± 6.4/48.3 ± 6.9 Flaxseed oil/25 ml 7 MDA (Ns) Raygan et al., 2019 Iran T2DM with CHD 30/30 62.0 ± 13.0/64.6 ± 9.1 Omega‐3 fatty acids from flaxseed oil/2000 mg 12 TAC (↑ ), MDA (↓ ), GSH (↑ ) Jamilian et al., 2020 Iran GDM 25/26 28.5 ± 4.1/29.5 ± 5.0 Omega-3 fatty acids from flaxseed oil/2000 mg 6 TAC (Ns), MDA (↓ ), GSH (↑ ) Rezaei et al., 2020 Iran NAFLD 34/34 40.8 ± 8.7/45.5 ± 8.7 Flaxseed oil/20 g 12 TAC (Ns), MDA (Ns)
DFU: diabetic foot ulcer; GDM: gestational diabetes mellitus; GSH: glutathione; MDA: malondialdehyde; T2DM: type 2 diabetes mellitus; CHD: coronary heart disease; TAC: total antioxidant capacity; NAFLD: nonalcoholic fatty liver disease.