Revealing the Mechanism of Friedelin in the Treatment of Ulcerative Colitis Based on Network Pharmacology and Experimental Verification

Figure 7

Friedelin regulated the DSS-induced autophagy-related proteins and AMPK-mTOR in DSS mice. (a) Friedelin activated levels of ATG5. (b) Friedelin activated levels of p-AMPK. (c) Friedelin inhibited levels of p-mTOR. Scale bar = 50 μm. Statistical differences compared with MD group were considered at  < 0.05,  < 0.01, or  < 0.001. Statistical differences compared between the 42 mg/kg group and the 42 mg/kg⁺³ ma group were considered at  < 0.05,  < 0.01, or  < 0.001.

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