Research on the Protective Effect of MiR-185-3p Mediated by Huangqin-Tang Decoction (HQT) on the Epithelial Barrier Function of Ulcerative Colitis

<div>Therapeutic effect of HQT on barrier function injury of DSS-induced ulcerative colitis (UC) mice. Experimental mice were given a gavage of 3% DSS for modeling for 7 days, and the mice in the HQT group were given a gavage of 4.55 g/kg HQT for treatment for 7 days. DAI score of mice in the control group, the DSS model group, and HQT (DSS model group plus HQT treatment) group (a); colon length and its statistics (b, c); colon tissue macroscopic score (d); pathological changes of colon were observed by HE staining (e) (200×; 1. villi, 2. crypt, 3. submucosa, 4. muscularis, 5. serosa); the relative expression quantity of colon occludin was tested by WB (f, g) and RT-PCR(H) (<i>n</i> = 8; <span class="nowrap"><svg height="15.3614pt" id="M7" style="vertical-align:-3.833899pt" version="1.1" viewbox="-0.0498162 -11.5275 49.7858 15.3614" width="49.7858pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g><g 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Evidence-Based Complementary and Alternative Medicine

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Figure 1

Figure 1: Research on the Protective Effect of MiR-185-3p Mediated by Huangqin-Tang Decoction (HQT) on the Epithelial Barrier Function of Ulcerative Colitis 

Figure 1 | Research on the Protective Effect of MiR-185-3p Mediated by Huangqin-Tang Decoction (HQT) on the Epithelial Barrier Function of Ulcerative Colitis 