Characterization of a Tumor-Microenvironment-Relevant Gene Set Based on Tumor Severity in Colon Cancer and Evaluation of Its Potential for Dihydroartemisinin Targeting

Figure 1

(a) Kaplan–Meier overall survival analysis of the 11 survival-associated TME genes in COAD. Differences were tested using the log-rank test. The median value of gene expression level was used as the group cutoff. Significant differences between the high-expression group and low-expression group of the 11 survival-associated TME genes in COAD were observed. (b) PPI analysis was carried out using the 11 survival-associated TME genes as the input. A PPI network was identified, including AEBP1, BGN, POSTN, and FAP. (c) Kaplan–Meier disease-free survival analysis of the STMERN in COAD. Differences were tested using the log-rank test. The median value of gene expression level was used as the group cutoff. Significant differences between the high-expression group and low-expression group of the 5 genes of the STMERN in COAD were observed. (d) Spearman’ s correlation analysis among the 5 genes of the STMERN in COAD tissues and normal tissues. Significantly higher correlations were observed among the 5 genes of the STMERN in COAD tissues compared to normal tissues.

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